CO2 laser hole drilling methods include direct method and Conformal mask into a hole two. Direct drilling technique is equipment main control system of laser beam passing through the diameter of the beam modulation with a diameter of holes on a printed circuit board by processing the same, without copper foil hole processing directly on the insulator surface. Conformal mask technique is in the printed circuit board surface coated with a layer mask, using conventional methods after exposure/developing/etching to remove surface of copper foil surface Conformal window. Then these holes is greater than the diameter of the laser beam is used, remove exposed layers of resin.